intestinal inflammatory — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4503	Talniflumate	Somalgen	Chloride channel , COX , N-Acetylglucosaminyltransferase , Anion Exchanger
	Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition o...
T2319	Acotiamide monohydrochloride trihydrate	Acotiamide hydrochloride,YM-443 HCl,Z-338 HCl	AChE
	Acotiamide monohydrochloride trihydrate (Z-338 HCl) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamid...		AChE
T21252	DHMB	2,3-Dihydroxy-4-Methoxybenzaldehyde	Others
	DHMB (2,3-Dihydroxy-4-Methoxybenzaldehyde) exerts protective effects on intestinal epithelial cells. DHMB exhibits anti-inflammatory and antifungal capacity.		Others
T5095	Oxazolone	4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one	Others
	Oxazolone has been used as a haptenizing agent, which can induce an inflammatory reaction in adult zebrafish intestinal tissues and this can be used as a model for gene expression studies of the two forms of inflammatory...		Others
T67710	3-Indoleacrylic acid		Endogenous Metabolite
	3-Indoleacrylic acid is a metabolite of tryptophan produced by Peptostreptococcus species. 3-Indoleacrylic acid has a beneficial effect on intestinal epithelial barrier function and mitigates inflammatory responses by im...		Endogenous Metabolite
T70084	Dersalazine	Dersalazine Free Base	IL Receptor , Platelet aggregation
	Dersalazine (Dersalazine Free Base), an inhibitor of platelet-activating factor, exerts intestinal anti-inflammatory activity in different rodent types of colitis by down-regulating IL-17 expression, with potential effic...		IL Receptor , Platelet aggregation
T8733	Antrodin A	camphorataanhydride A	Others
	Antrodin A (camphorataanhydride A) (AdA) is one of the main active ingredients in the solid-state fermented A. camphorata mycelium. It protects the liver from alcohol damage by improving the antioxidant and anti-inflamma...		Others
T13920L	Terlipressin Acetate	Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous	Vasopressin Receptor
	Terlipressin Acetate, a highly selective vasopressin V1 receptor agonist, on oxygen and glucose deprivation/re-oxygenation (OGD/R)-induced damage in intestinal epithelial cells (IEC-6).Terlipressin acetate exerts anti-in...		Vasopressin Receptor
T13647	Dextran sulfate sodium salt (MW 4500-5500)	DSS,Dextran sulfate sodium salt (MW 4500-5500)	Apoptosis , HIV Protease
	Dextran sulfate sodium salt (MW 4500-5500) is an anhydrous glucose polymer with a molecular weight range of 4500-5500. Dextran sulfate sodium salt (MW 4500-5500) inhibits human immunodeficiency virus replication by preve...		Apoptosis , HIV Protease
T5S1177	Aloin B	Isobarbaloin	Others
	Aloin B (Isobarbaloin) is an isomer of aloin.1. The extract of A. vera and its active ingredient aloin cause melanin aggregation leading to skin lightening via alpha adrenergic receptor stimulation, the result opens new ...		Others
T3123	Allicin		ERK , IL Receptor , Others , IκB/IKK , p38 MAPK , TNF , ROS , Caspase , Antifection
	Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth mus...
T4938	Potassium 1H-indol-3-yl sulfate	Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate	AhR , Endogenous Metabolite
	Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of imm...		AhR , Endogenous Metabolite
TP1487	Glucagon-Like Peptide (GLP) II, human
	Glucagon-like peptide 2 (GLP-2) is a recently identified intestinal epithelium-specific growth factor that has been shown to reduce the severity of inflammatory disorders of the intestine in rodent models. Currently Gluc...
T38499	κ-Carrageenan
	κ-Carrageenan, a natural polymer found predominantly in red seaweeds, can serve as an effective drug carrier for delivering curcumin to cancer cells and inducing apoptosis. Additionally, κ-Carrageenan holds promise as a ...
T39874	GSK143 dihydrochloride
	GSK143 dihydrochloride is a highly selective, orally active inhibitor of spleen tyrosine kinase (SYK), exhibiting a pIC 50 value of 7.5. It effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of 7.1. The c...
T79809	ROCK-IN-8		ROCK
	ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research, demonstrating an IC50 value below 100 nM [1].		ROCK
T38626	GSK143
	GSK143 is a potent orally active and highly selective inhibitor of spleen tyrosine kinase (SYK) with a pIC 50 of 7.5. Furthermore, GSK143 effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of 7.1. In addi...
TN5147	Tilifodiolide		IL Receptor , TNF , GABA Receptor
	Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreasing the intestinal fluid accumulation and vasorelaxant effe...		IL Receptor , TNF , GABA Receptor
T62959	LRH-1 modulator-1
	LRH-1 modulator-1 is a potent modulator/agonist of LRH-1 (liver receptor homolog-1). LRH-1 modulator-1 induces the anti-inflammatory cytokine IL-10 and exhibits inhibition of the inflammatory cytokines IL-1b and TNFa. LR...
T82773	Catechin 7-O-β-D-glucopyranoside
	Catechin 7-O-β-D-glucopyranoside, a natural product identified in Ulmus davidiana and Paeonia obovata, demonstrates oral activity and possesses antioxidant and anti-inflammatory properties. It mitigates mitochondrial dys...